Thymic Presentation of Autoantigens and the Efficiency of Negative Selection

DOI10.1080/102736620310001604910zbMath1042.92008OpenAlexW2009623990MaRDI QIDQ4453931

Carmen Molina-París, Hugo Antonius van den Berg

Publication date: 7 March 2004

Published in: Journal of Theoretical Medicine (Search for Journal in Brave)

Full work available at URL: https://eudml.org/doc/223874

zbMATH Keywords

large deviations theorynegative selectionautoimmunity\(T\) cell tolerance

Mathematics Subject Classification ID

Medical applications (general) (92C50) Physiology (general) (92C30) Cell biology (92C37)

Related Items (7)

Foreignness as a matter of degree: the relative immunogenicity of peptide/MHC ligands ⋮ Dynamics of T cell activation threshold tuning ⋮ Coreceptor CD8-driven modulation of T cell antigen receptor specificity ⋮ How T-cells use large deviations to recognize foreign antigens ⋮ Stochastic modelling of T-cell activation ⋮ Stochastic niche structure and diversity maintenance in the T cell repertoire ⋮ Rare event simulation for T-cell activation

Cites Work

• Quantifying the strength of ligand antagonism in TCR triggering

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