Thymic Presentation of Autoantigens and the Efficiency of Negative Selection

DOI10.1080/102736620310001604910MaRDI QIDQ4453931zbMATH OpenOpenAlexFDO

Authors Carmen Molina-París, Hugo A. van den Berg

Publication date 7 March 2004

Published in Journal of Theoretical Medicine (Search for Journal in Brave)

Full work available at URL https://eudml.org/doc/223874

zbMATH Keywords

large deviations theorynegative selectionautoimmunity\(T\) cell tolerance

Mathematics Subject Classification ID

Medical applications (general) (92C50) Physiology (general) (92C30) Cell biology (92C37)

Recommendations

• The dual role of autoimmune regulator in maintaining normal expression level of tissue-restricted autoantigen in the thymus: a modeling investigation
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• Explaining high alloreactivity as a quantitative consequence of affinity-driven thymocyte selection
• Autoimmunity arising from bystander proliferation of T cells in an immune response model
• Self-tolerance and autoimmunity in a regulatory T cell model
• T cell anergy as a strategy to reduce the risk of autoimmunity
• Thymic selection of T cells as diffusion with intermittent traps
• Self-tolerance and autoimmunity in a minimal model of the idiotypic network

Cites work

• Quantifying the strength of ligand antagonism in TCR triggering

Cited in

(14)

• Antigen presentation on MHC molecules as a diversity filter that enhances immune efficacy
• The influence of T cell development on pathogen specificity and autoreactivity
• How T-cells use large deviations to recognize foreign antigens
• Coreceptor CD8-driven modulation of T cell antigen receptor specificity
• Foreignness as a matter of degree: the relative immunogenicity of peptide/MHC ligands
• The effects of affinity mediated clonal expansion of premigrant thymocytes on the periphery T-cell repertoire
• Rare event simulation for T-cell activation
• Stochastic modelling of T-cell activation
• Thymic selection of T cells as diffusion with intermittent traps
• Stochastic niche structure and diversity maintenance in the T cell repertoire
• Explaining high alloreactivity as a quantitative consequence of affinity-driven thymocyte selection
• Dynamics of T cell activation threshold tuning
• The dual role of autoimmune regulator in maintaining normal expression level of tissue-restricted autoantigen in the thymus: a modeling investigation
• T cell anergy as a strategy to reduce the risk of autoimmunity

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