Determining identifiable parameter combinations using subset profiling
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Publication:464516
DOI10.1016/J.MBS.2014.08.008zbMATH Open1330.92009arXiv1307.2298OpenAlexW1991238279WikidataQ51045921 ScholiaQ51045921MaRDI QIDQ464516FDOQ464516
Michael A. L. Hayashi, Marisa C. Eisenberg
Publication date: 27 October 2014
Published in: Mathematical Biosciences (Search for Journal in Brave)
Abstract: Identifiability is a necessary condition for successful parameter estimation of dynamic system models. A major component of identifiability analysis is determining the identifiable parameter combinations, the functional forms for the dependencies between unidentifiable parameters. Identifiable combinations can help in model reparameterization and also in determining which parameters may be experimentally measured to recover model identifiability. Several numerical approaches to determining identifiability of differential equation models have been developed, however the question of determining identifiable combinations remains incompletely addressed. In this paper, we present a new approach which uses parameter subset selection methods based on the Fisher Information Matrix, together with the profile likelihood, to effectively estimate identifiable combinations. We demonstrate this approach on several example models in pharmacokinetics, cellular biology, and physiology.
Full work available at URL: https://arxiv.org/abs/1307.2298
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Cited In (26)
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