Nonnegative Linear Elimination for Chemical Reaction Networks
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Publication:5205261
DOI10.1137/18M1197692zbMATH Open1429.92076arXiv1807.00061OpenAlexW2996719774WikidataQ126584762 ScholiaQ126584762MaRDI QIDQ5205261FDOQ5205261
Authors: Meritxell Sáez, Carsten Wiuf, Elisenda Feliu 
Publication date: 11 December 2019
Published in: SIAM Journal on Applied Mathematics (Search for Journal in Brave)
Abstract: We consider linear elimination of variables in steady state equations of a chemical reaction network. Particular subsets of variables corresponding to sets of so-called reactant-noninteracting species, are introduced. The steady state equations for the variables in such a set, taken together with potential linear conservation laws in the variables, define a linear system of equations. We give conditions that guarantee that the solution to this system is nonnegative, provided it is unique. The results are framed in terms of spanning forests of a particular multidigraph derived from the reaction network and thereby conditions for uniqueness and nonnegativity of a solution are derived by means of the multidigraph. Though our motivation comes from applications in systems biology, the results have general applicability in applied sciences.
Full work available at URL: https://arxiv.org/abs/1807.00061
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Systems biology, networks (92C42) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)
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Cited In (12)
- Variable elimination in post-translational modification reaction networks with mass-action kinetics
- Linear elimination in chemical reaction networks
- Conditions for extinction events in chemical reaction networks with discrete state spaces
- Computing complex chemical equilibria by generalized linear programming
- Critical parameters for singular perturbation reductions of chemical reaction networks
- Graphical criteria for positive solutions to linear systems
- Conservation laws in biochemical reaction networks
- Variable elimination in chemical reaction networks with mass-action kinetics
- How to generate species with positive concentrations for all positive times?
- Symbolic Proof of Bistability in Reaction Networks
- Neville elimination: An efficient algorithm with application to chemistry
- A computational approach to extinction events in chemical reaction networks with discrete state spaces
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