Nonnegative Linear Elimination for Chemical Reaction Networks
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Publication:5205261
Abstract: We consider linear elimination of variables in steady state equations of a chemical reaction network. Particular subsets of variables corresponding to sets of so-called reactant-noninteracting species, are introduced. The steady state equations for the variables in such a set, taken together with potential linear conservation laws in the variables, define a linear system of equations. We give conditions that guarantee that the solution to this system is nonnegative, provided it is unique. The results are framed in terms of spanning forests of a particular multidigraph derived from the reaction network and thereby conditions for uniqueness and nonnegativity of a solution are derived by means of the multidigraph. Though our motivation comes from applications in systems biology, the results have general applicability in applied sciences.
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Cited in
(12)- Variable elimination in post-translational modification reaction networks with mass-action kinetics
- Conditions for extinction events in chemical reaction networks with discrete state spaces
- Linear elimination in chemical reaction networks
- Computing complex chemical equilibria by generalized linear programming
- Graphical criteria for positive solutions to linear systems
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- Variable elimination in chemical reaction networks with mass-action kinetics
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- Symbolic Proof of Bistability in Reaction Networks
- Neville elimination: An efficient algorithm with application to chemistry
- A computational approach to extinction events in chemical reaction networks with discrete state spaces
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