Generalized mass action systems: complex balancing equilibria and sign vectors of the stoichiometric and kinetic-order subspaces

DOI10.1137/110847056MaRDI QIDQ4915212zbMATH OpenOpenAlexFDO

Authors Stefan Müller, Georg Regensburger

Publication date 9 April 2013

Published in SIAM Journal on Applied Mathematics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1209.6488

zbMATH Keywords

generalized mass action kineticsoriented matroidschemical reaction network theorycomplex balancinggeneralized Birch's theorem

Mathematics Subject Classification ID

Systems biology, networks (92C42) Classical flows, reactions, etc. in chemistry (92E20)

Abstract: Mass action systems capture chemical reaction networks in homogeneous and dilute solutions. We suggest a notion of generalized mass action systems that admits arbitrary nonnegative power-law rate functions and serves as a more realistic model for reaction networks in intracellular environments. In addition to the chemical complexes and the related stoichiometric subspace, we introduce corresponding kinetic complexes, which represent the nonnegative exponents in the rate functions and determine the kinetic-order subspace. We show that several results of Chemical Reaction Network Theory carry over to the case of generalized mass action kinetics. Our main result essentially states that, if the sign vectors of the stoichiometric and the kinetic-order subspace coincide, there exists a unique positive complex balancing equilibrium in every stoichiometric compatibility class. However, in contrast to classical mass action systems, multiple complex balancing equilibria in one stoichiometric compatibility class are possible in general.

Recommendations

• Generalized mass-action systems and positive solutions of polynomial equations with real and symbolic exponents (invited talk)
• A generalization of Birch's theorem and vertex-balanced steady states for generalized mass-action systems
• Complex-balanced equilibria of generalized mass-action systems: necessary conditions for linear stability
• scientific article; zbMATH DE number 7414723
• How far is complex balancing from detailed balancing?

Cited in

(63)

• Comparative analysis of carbon cycle models via kinetic representations
• Nonnegative Linear Elimination for Chemical Reaction Networks
• Sign conditions for the existence of at least one positive solution of a sparse polynomial system
• A decomposition-based approach for deriving positive steady states of a class of chemical reaction networks with non-mass-action kinetics
• The Disguised Toric Locus and Affine Equivalence of Reaction Networks
• Generic consistency and nondegeneracy of vertically parametrized systems
• Reaction networks and kinetics of biochemical systems
• Positive equilibria of power law kinetics on networks with independent linkage classes
• The center problem for the Lotka reactions with generalized mass-action kinetics
• A deficiency-one algorithm for power-law kinetic systems with reactant-determined interactions
• Absolutely Complex Balanced Kinetic Systems
• Oscillatory behavior in discrete slow power-law models
• Positive steady states of a class of power law systems with independent decompositions
• Embedding-based comparison of reaction networks of Wnt signaling
• Graphically balanced equilibria and stationary measures of reaction networks
• Model of complex chiral drug metabolic systems and numerical simulation of the remaining chirality toward analysis of dynamical pharmacological activity
• Planar S-systems: global stability and the center problem
• Weakly reversible realizations of biochemical systems theory (BST) models
• Node balanced steady states: unifying and generalizing complex and detailed balanced steady states
• Persistence and stability of a class of kinetic compartmental models
• A computational approach to multistationarity of power-law kinetic systems
• On global stability of the Lotka reactions with generalized mass-action kinetics
• Translated chemical reaction networks
• How far is complex balancing from detailed balancing?
• On the bijectivity of families of exponential/generalized polynomial maps
• A deficiency-based approach to parametrizing positive equilibria of biochemical reaction systems
• Realizations of quasi-polynomial systems and application for stability analysis
• Network translation and steady-state properties of chemical reaction systems
• A generalization of Birch's theorem and vertex-balanced steady states for generalized mass-action systems
• Complex-balanced equilibria of generalized mass-action systems: necessary conditions for linear stability
• Sufficient Conditions for Linear Stability of Complex-Balanced Equilibria in Generalized Mass-Action Systems
• The long-term impact of direct capture approaches to carbon dioxide removal
• Linear conjugacy in biochemical reaction networks with rational reaction rates
• Sign conditions for injectivity of generalized polynomial maps with applications to chemical reaction networks and real algebraic geometry
• Characterizing injectivity of classes of maps via classes of matrices
• Computational Translation Framework Identifies Biochemical Reaction Networks with Special Topologies and Their Long-Term Dynamics
• Generalized mass-action systems and positive solutions of polynomial equations with real and symbolic exponents (invited talk)
• A SageMath package for elementary and sign vectors with applications to chemical reaction networks
• Detection of Hopf bifurcations in chemical reaction networks using convex coordinates
• A computational approach to steady state correspondence of regular and generalized mass action systems
• Chemical reaction network approaches to biochemical systems theory
• Parameter-minimal analysis of carbon dioxide removal through direct air capture
• Network transformation-based analysis of biochemical systems
• Complex Balanced Equilibria of Weakly Reversible Poly-Pl Systems: Existence, Stability, and Robustness
• Single-target networks
• Parametrized systems of generalized polynomial inequalities via linear algebra and convex geometry
• A network-based parametrization of positive steady states of power-law kinetic systems
• Analysis of mass-action systems by split network translation
• Computing weakly reversible deficiency zero network translations using elementary flux modes
• Robustness in power-law kinetic systems with reactant-determined interactions
• Existence of a unique quasi-stationary distribution in stochastic reaction networks
• Independent, incidence independent and weakly reversible decompositions of chemical reaction networks
• A path method for non-exponential ergodicity of Markov chains and its application for chemical reaction systems
• Symbolic Proof of Bistability in Reaction Networks
• Unstable cores are the source of instability in chemical reaction networks
• A new decomposition of the graph Laplacian and the binomial structure of mass-action systems
• Enzyme allocation problems in kinetic metabolic networks: optimal solutions are elementary flux modes
• Maximum likelihood estimation of log-affine models using detailed-balanced reaction networks
• A computational approach to linear conjugacy in a class of power law kinetic systems
• Positive equilibria of a class of power-law kinetics
• Reactant subspaces and kinetics of chemical reaction networks
• Positive equilibria of weakly reversible power law kinetic systems with linear independent interactions
• Mass action systems: two criteria for Hopf bifurcation without Hurwitz

This page was built for publication: Generalized mass action systems: complex balancing equilibria and sign vectors of the stoichiometric and kinetic-order subspaces

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q4915212)