Optimal adaptive control of drug dosing using integral reinforcement learning

DOI10.1016/J.MBS.2019.01.012zbMATH Open1409.92119OpenAlexW2911236815WikidataQ91421621 ScholiaQ91421621MaRDI QIDQ669203FDOQ669203

Authors: Regina Padmanabhan, Nader Meskin, Wassim M. Haddad 

Publication date: 20 March 2019

Published in: Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.mbs.2019.01.012

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zbMATH Keywords

reinforcement learningdrug dosinganesthesia administrationoptimal adaptive control

Mathematics Subject Classification ID

Medical applications (general) (92C50) Feedback control (93B52) Adaptive control/observation systems (93C40)

Cites Work

• Reinforcement learning strategies for clinical trials in nonsmall cell lung cancer
• Nonnegative and compartmental dynamical systems
• Optimal adaptive control and differential games by reinforcement learning principles
• Linear Quadratic Tracking Control of Partially-Unknown Continuous-Time Systems Using Reinforcement Learning
• Adaptive control for non-negative and compartmental dynamical systems with applications to general anesthesia
• Reinforcement learning-based control of drug dosing for cancer chemotherapy treatment
• Clinical decision support and closed-loop control for intensive care unit sedation
• On the concept of excitation in least squares identification and adaptive control^†
• Optimal drug dosing control for intensive care unit sedation by using a hybrid deterministic-stochastic pharmacokinetic and pharmacodynamic model

Cited In (8)

• Model-based control algorithm for medication dosing under incomplete information about the state of the organism
• Reinforcement learning-based control of drug dosing for cancer chemotherapy treatment
• Optimal drug dosing control for intensive care unit sedation by using a hybrid deterministic-stochastic pharmacokinetic and pharmacodynamic model
• Coordinated semi-adaptive closed-loop control for infusion of two interacting medications
• Differential flatness properties and multivariable adaptive fuzzy control of hormonal system dynamics
• A semi‐adaptive control approach to closed‐loop medication infusion
• Editorial. The application of machine learning to disease diagnosis and treatment
• Optimal control of midazolam infusion for post operative patients in intensive care units

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