Stochastic population switch may explain the latent reservoir stability and intermittent viral blips in HIV patients on suppressive therapy

DOI10.1016/j.jtbi.2014.06.042zbMath1343.92285OpenAlexW1976952734WikidataQ42206609 ScholiaQ42206609MaRDI QIDQ739681

Sunpeng Wang, Libin Rong

Publication date: 19 August 2016

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jtbi.2014.06.042

zbMATH Keywords

mathematical modelstochastic simulationviral persistenceHIV latencyactivation therapy

Mathematics Subject Classification ID

Medical applications (general) (92C50) Medical epidemiology (92C60)

Related Items (12)

Dynamics of an HIV model with multiple infection stages and treatment with different drug classes ⋮ Stochastic modelling of viral blips in HIV-1-infected patients: effects of inhomogeneous density fluctuations ⋮ Periodic Solutions of an Infected-Age Structured HIV Model with the Latent Factor and Different Transmission Modes ⋮ A stochastic delay model of HIV pathogenesis with reactivation of latent reservoirs ⋮ HIV infection dynamics and viral rebound: modeling results from humanized mice ⋮ Analysis of HIV models with two time delays ⋮ An HIV model with age-structured latently infected cells ⋮ The role of CD4 T cells in immune system activation and viral reproduction in a simple model for HIV infection ⋮ Immuno-modulatory strategies for reduction of HIV reservoir cells ⋮ Modeling HIV dynamics under combination therapy with inducers and antibodies ⋮ Dynamics of a new HIV model with the activation status of infected cells ⋮ Analysis of an HIV model with post-treatment control

Cites Work

• Opportunistic infection as a cause of transient viremia in chronically infected HIV patients under treatment with HAART
• Monte Carlo estimates of natural variation in HIV infection
• Asymmetric division of activated latently infected cells may explain the decay kinetics of the HIV-1 latent reservoir and intermittent viral blips
• Modeling HIV persistence, the latent reservoir, and viral blips
• Latently infected cell activation: a way to reduce the size of the HIV reservoir?
• Dynamics of HIV infection of CD4\(^ +\) T cells
• Conditions for Transient Viremia in Deterministic in-Host Models: Viral Blips Need No Exogenous Trigger

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