Assessing phenotypic correlation through the multivariate phylogenetic latent liability model
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Publication:746692
DOI10.1214/15-AOAS821zbMATH Open1454.62324arXiv1406.3863WikidataQ36763244 ScholiaQ36763244MaRDI QIDQ746692FDOQ746692
Authors: Gabriela B. Cybis, Janet S. Sinsheimer, Trevor Bedford, Alison E. Mather, Philippe Lemey, Marc A. Suchard 
Publication date: 28 October 2015
Published in: The Annals of Applied Statistics (Search for Journal in Brave)
Abstract: Understanding which phenotypic traits are consistently correlated throughout evolution is a highly pertinent problem in modern evolutionary biology. Here, we propose a multivariate phylogenetic latent liability model for assessing the correlation between multiple types of data, while simultaneously controlling for their unknown shared evolutionary history informed through molecular sequences. The latent formulation enables us to consider in a single model combinations of continuous traits, discrete binary traits and discrete traits with multiple ordered and unordered states. Previous approaches have entertained a single data type generally along a fixed history, precluding estimation of correlation between traits and ignoring uncertainty in the history. We implement our model in a Bayesian phylogenetic framework, and discuss inference techniques for hypothesis testing. Finally, we showcase the method through applications to columbine flower morphology, antibiotic resistance in Salmonella and epitope evolution in influenza.
Full work available at URL: https://arxiv.org/abs/1406.3863
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Cites Work
- Assessing phenotypic correlation through the multivariate phylogenetic latent liability model
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- Massive Parallelization Boosts Big Bayesian Multidimensional Scaling
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