Exact computation of amplification for a class of nonlinear systems arising from cellular signaling pathways

DOI10.1016/J.AUTOMATICA.2006.06.011zbMATH Open1130.93366arXivq-bio/0408012OpenAlexW2145635212MaRDI QIDQ880397FDOQ880397

Authors: Madalena Chaves, Eduardo D. Sontag 

Publication date: 15 May 2007

Published in: Automatica (Search for Journal in Brave)

Abstract: A commonly employed measure of the signal amplification properties of an input/output system is its induced L2 norm, sometimes also known as "H infinity" gain. In general, however, it is extremely difficult to compute the numerical value for this norm, or even to check that it is finite, unless the system being studied is linear. This paper describes a class of systems for which it is possible to reduce this computation to that of finding the norm of an associated linear system. In contrast to linearization approaches, a precise value, not an estimate, is obtained for the full nonlinear model. The class of systems that we study arose from the modeling of certain biological intracellular signaling cascades, but the results should be of wider applicability.

Full work available at URL: https://arxiv.org/abs/q-bio/0408012

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zbMATH Keywords

gainsnonlinear systemsnormssignaling pathways

Mathematics Subject Classification ID

Nonlinear systems in control theory (93C10) Control/observation systems governed by ordinary differential equations (93C15) Fault detection; testing in circuits and networks (94C12)

Cites Work

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• L/sub 2/-gain analysis of nonlinear systems and nonlinear state-feedback H/sub infinity / control
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Cited In (2)

• A model of amplification
• No-oscillation theorem for the transient dynamics of the linear signal transduction pathway and beyond

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