Exact computation of amplification for a class of nonlinear systems arising from cellular signaling pathways

DOI10.1016/J.AUTOMATICA.2006.06.011MaRDI QIDQ880397zbMATHOpenAlexFDO

Authors Madalena Chaves, Eduardo D. Sontag

Publication date 15 May 2007

Published in Automatica (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/q-bio/0408012

zbMATH Keywords

gainsnonlinear systemsnormssignaling pathways

Mathematics Subject Classification ID

Nonlinear systems in control theory (93C10) Control/observation systems governed by ordinary differential equations (93C15) Fault detection; testing in circuits and networks (94C12)

Abstract: A commonly employed measure of the signal amplification properties of an input/output system is its induced L2 norm, sometimes also known as "H infinity" gain. In general, however, it is extremely difficult to compute the numerical value for this norm, or even to check that it is finite, unless the system being studied is linear. This paper describes a class of systems for which it is possible to reduce this computation to that of finding the norm of an associated linear system. In contrast to linearization approaches, a precise value, not an estimate, is obtained for the full nonlinear model. The class of systems that we study arose from the modeling of certain biological intracellular signaling cascades, but the results should be of wider applicability.

Recommendations

• Asymptotic amplitudes and Cauchy gains: A small-gain principle and an application to inhibitory biological feedback
• On system gains for linear and nonlinear systems
• Performance bounds for nonlinear systems with a nonlinear \(\mathcal L_{2}\)-gain property
• Numerical approximation of the \(H_ \infty\) norm of nonlinear systems
• Nonlinear \(\mathcal{L}_2\)-gain verification for nonlinear systems

Cites work

• scientific article; zbMATH DE number 1182386 (Why is no real title available?)
• scientific article; zbMATH DE number 758785 (Why is no real title available?)
• scientific article; zbMATH DE number 3282899 (Why is no real title available?)
• H/sup infinity / control for nonlinear systems with output feedback
• L/sub 2/-gain analysis of nonlinear systems and nonlinear state-feedback H/sub infinity / control
• Monotone control systems

Cited in

(2)

• A model of amplification
• No-oscillation theorem for the transient dynamics of the linear signal transduction pathway and beyond

This page was built for publication: Exact computation of amplification for a class of nonlinear systems arising from cellular signaling pathways

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q880397)