Genome-wide significance levels and weighted hypothesis testing

DOI10.1214/09-STS289zbMath1329.62435arXiv1010.4637OpenAlexW3102202397WikidataQ34061938 ScholiaQ34061938MaRDI QIDQ908107

Kathryn Roeder, Larry Alan Wasserman

Publication date: 3 February 2016

Published in: Statistical Science (Search for Journal in Brave)

Full work available at URL: https://arxiv.org/abs/1010.4637

zbMATH Keywords

multiple testingBonferroni correctionweighted \(p\)-values

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Genetics and epigenetics (92D10) Paired and multiple comparisons; multiple testing (62J15)

Related Items (30)

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Uses Software

• ElemStatLearn

Cites Work

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• Control of the false discovery rate under dependence using the bootstrap and subsampling
• The control of the false discovery rate in multiple testing under dependency.
• Some results on false discovery rate in stepwise multiple testing procedures.
• Higher criticism for detecting sparse heterogeneous mixtures.
• Nonparametric multiple test procedures with data-driven order of hypotheses and with weighted hypotheses
• Two simple sufficient conditions for FDR control
• Optimal weighting for false discovery rate control
• Simultaneous inference: when should hypothesis testing problems be combined?
• Adaptive FDR control under independence and dependence
• Adaptive linear step-up procedures that control the false discovery rate
• False discovery control with p-value weighting
• Oracle and Adaptive Compound Decision Rules for False Discovery Rate Control
• Multiple Hypotheses Testing with Weights
• Using Priors to Improve Multiple Animal Carcinogenicity Tests
• Empirical Bayes Analysis of a Microarray Experiment
• A Direct Approach to False Discovery Rates
• Operating Characteristics and Extensions of the False Discovery Rate Procedure
• Weighted p‐Value Adjustments for Animal Carcinogenicity Trend Test
• A Method to Increase the Power of Multiple Testing Procedures Through Sample Splitting
• Statistical significance for genomewide studies
• The elements of statistical learning. Data mining, inference, and prediction
• Optimally weighted, fixed sequence and gatekeeper multiple testing procedures

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