Krylov and steady-state techniques for the solution of the chemical master equation for the mitogen-activated protein kinase cascade

DOI10.1007/S11075-008-9239-YzbMath1165.92019OpenAlexW2099263825MaRDI QIDQ1027792

Shev MacNamara, Kevin Burrage

Publication date: 30 June 2009

Published in: Numerical Algorithms (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1007/s11075-008-9239-y

zbMATH Keywords

stochastic simulationsKrylov subspace approximationstotal steady state approximations

Mathematics Subject Classification ID

Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Computational methods for stochastic equations (aspects of stochastic analysis) (60H35) Numerical solutions to stochastic differential and integral equations (65C30)

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New trends and perspectives in nonlinear intracellular dynamics: one century from Michaelis-Menten paper ⋮ Uniform Asymptotic Expansions beyond the tQSSA for the Goldbeter--Koshland Switch ⋮ A study case for the analysis of asymptotic expansions beyond the tQSSA for inhibitory mechanisms in enzyme kinetics.

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