Empirical Bayes analysis of unreplicated microarray data

DOI10.1007/S00180-008-0133-9MaRDI QIDQ964653zbMATH OpenOpenAlexFDO

Authors B. E. Eshmatov

Publication date 22 April 2010

Published in Computational Statistics (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1007/s00180-008-0133-9

zbMATH Keywords

heterogeneous errorMarkov chain Monte-CarloMCMCtwo-way ANOVA

Mathematics Subject Classification ID

Empirical decision procedures; empirical Bayes procedures (62C12) Analysis of variance and covariance (ANOVA) (62J10) Applications of statistics to biology and medical sciences; meta analysis (62P10) Numerical analysis or methods applied to Markov chains (65C40) Biochemistry, molecular biology (92C40)

Review text

A microarray analysis technique is developed for the analysis of unreplicated gene expression data. It is based on a two-way ANOVA model with heterogeneous errors. A Bayesisan approach is used for the parameter estimation with Markov chain Monte-Carlo techniques for the evaluation of the estimates. An empirical Bayes approach is proposed for the data variance priors specifications. The performance of the proposed methods is assessed by real data and via simulations.

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Cites work

• Bayesian Models for Gene Expression With DNA Microarray Data
• Detecting Differentially Expressed Genes in Microarrays Using Bayesian Model Selection
• Empirical Bayes Analysis of a Microarray Experiment
• scientific article; zbMATH DE number 774836 (Why is no real title available?)
• Importance of replication in microarray gene expression studies: Statistical methods and evidence from repetitive cDNA hybridizations
• Practical Markov Chain Monte Carlo
• Robbins, empirical Bayes and microarrays
• Significance analysis of microarrays applied to the ionizing radiation response

Cited in

(14)

• An empirical Bayes' approach to joint analysis of multiple microarray gene expression studies
• A bootstrap-based non-parametric ANOVA method with applications to factorial microarray data
• Empirical Bayes Analysis of a Microarray Experiment
• scientific article; zbMATH DE number 1750180 (Why is no real title available?)
• scientific article; zbMATH DE number 1750188 (Why is no real title available?)
• Empirical and fully Bayesian approaches for random effects models in microarray data analysis
• An automatic thresholding approach to gene expression analysis
• Empirical Bayes Microarray ANOVA and Grouping Cell Lines by Equal Expression Levels
• Incorporating Biological Information as a Prior in an Empirical Bayes Approach to Analyzing Microarray Data
• Statistical analysis of microarray data: a Bayesian approach
• Empirical Bayes methods for DNA microarray data
• Rejoinder: ``Microarrays, empirical Bayes and the two-groups model
• Laplace approximated EM microarray analysis: an empirical Bayes approach for comparative microarray experiments
• A heavy-tailed empirical Bayes method for replicated microarray data

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Uses Software

• EBarrays

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