Laplace approximated EM microarray analysis: an empirical Bayes approach for comparative microarray experiments

DOI10.1214/10-STS339zbMath1329.62114arXiv1101.0905MaRDI QIDQ906537

Martin T. Wells, James G. Booth, Haim Y. Bar, Elizabeth D. Schifano

Publication date: 22 January 2016

Published in: Statistical Science (Search for Journal in Brave)

Full work available at URL: https://arxiv.org/abs/1101.0905

zbMATH Keywords

EM algorithmempirical Bayeslinear mixed modelsLaplace approximationmixture modelmicroarray analysislocal false discovery ratetwo-groups modelLEMMALIMMA

Mathematics Subject Classification ID

Asymptotic properties of parametric estimators (62F12) Classification and discrimination; cluster analysis (statistical aspects) (62H30) Applications of statistics to biology and medical sciences; meta analysis (62P10) Design of statistical experiments (62K99) Bayesian inference (62F15) Paired and multiple comparisons; multiple testing (62J15)

Related Items (5)

Finding causative genes from high-dimensional data: an appraisal of statistical and machine learning approaches ⋮ Robust semiparametric optimal testing procedure for multiple normal means ⋮ Empirical and fully Bayesian approaches for random effects models in microarray data analysis ⋮ A three-groups model for high-throughput survival screens ⋮ lemma

Uses Software

• R
• Bioconductor
• gcrma
• limma
• RankGene
• locfdr

Cites Work

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• Improved statistical tests for differential gene expression by shrinking variance components estimates
• Empirical Bayes Microarray ANOVA and Grouping Cell Lines by Equal Expression Levels
• A Bayesian Mixture Model for Differential Gene Expression

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