The recovery of a recessive allele in a Mendelian diploid model

DOI10.1007/S00285-018-1240-ZzbMATH Open1415.92123arXiv1703.02459OpenAlexW2962737513WikidataQ88601039 ScholiaQ88601039MaRDI QIDQ1784418FDOQ1784418

Authors: Anton Bovier, Loren Coquille, Rebecca Neukirch 

Publication date: 26 September 2018

Published in: Journal of Mathematical Biology (Search for Journal in Brave)

Abstract: We study the large population limit of a stochastic individual-based model which describes the time evolution of a diploid hermaphroditic population reproducing according to Mendelian rules. In [Neukirch, Bovier, 2016] it is proved that sexual reproduction allows unfit alleles to survive in individuals with mixed genotype much longer than they would in populations reproducing asexually. In the present paper we prove that this indeed opens the possibility that individuals with a pure genotype can reinvade in the population after the appearance of further mutations. We thus expose a formal description of a mechanism by which a recessive allele can re-emerge in a population. This can be seen as a statement of genetic robustness exhibited by diploid populations performing sexual reproduction.

Full work available at URL: https://arxiv.org/abs/1703.02459

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zbMATH Keywords

adaptive dynamicspopulation dynamicsdiploid populationgenetic variabilityMendelian reproductionnonlinear birth-and-death process

Mathematics Subject Classification ID

Genetics and epigenetics (92D10) Applications of branching processes (60J85) Population dynamics (general) (92D25)

Cites Work

• The dynamical theory of coevolution: A derivation from stochastic ecological processes
• Mathematical population genetics. I: Theoretical introduction.
• Title not available (Why is that?)
• Title not available (Why is that?)
• From Individual Stochastic Processes to Macroscopic Models in Adaptive Evolution
• A rigorous model study of the adaptive dynamics of Mendelian diploids
• Title not available (Why is that?)
• Title not available (Why is that?)
• Polymorphic evolution sequence and evolutionary branching
• Title not available (Why is that?)
• A microscopic interpretation for adaptive dynamics trait substitution sequence models
• Adaptive dynamics and evolutionary stability
• A microscopic probabilistic description of a locally regulated population and macroscopic approximations
• The interplay of two mutations in a population of varying size: A stochastic eco-evolutionary model for clonal interference
• Stochastic modeling of density-dependent diploid populations and the extinction vortex
• Slow-fast stochastic diffusion dynamics and quasi-stationarity for diploid populations with varying size
• Survival of a recessive allele in a Mendelian diploid model
• From stochastic, individual-based models to the canonical equation of adaptive dynamics in one step

Cited In (8)

• From adaptive dynamics to adaptive walks
• Stochastic modeling of density-dependent diploid populations and the extinction vortex
• On \(\Lambda\)-Fleming-Viot processes with general frequency-dependent selection
• Crossing a fitness valley as a metastable transition in a stochastic population model
• Survival of a recessive allele in a Mendelian diploid model
• A general multi-scale description of metastable adaptive motion across fitness valleys
• Sharp approximation and hitting times for stochastic invasion processes
• Emergence of clones in sexual populations

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