Structural nested models and G-estimation: the partially realized promise
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Publication:252829
DOI10.1214/14-STS493zbMATH Open1331.62208arXiv1503.01589WikidataQ58819034 ScholiaQ58819034MaRDI QIDQ252829FDOQ252829
Marshall M. Joffe, Stijn Vansteelandt
Publication date: 4 March 2016
Published in: Statistical Science (Search for Journal in Brave)
Abstract: Structural nested models (SNMs) and the associated method of G-estimation were first proposed by James Robins over two decades ago as approaches to modeling and estimating the joint effects of a sequence of treatments or exposures. The models and estimation methods have since been extended to dealing with a broader series of problems, and have considerable advantages over the other methods developed for estimating such joint effects. Despite these advantages, the application of these methods in applied research has been relatively infrequent; we view this as unfortunate. To remedy this, we provide an overview of the models and estimation methods as developed, primarily by Robins, over the years. We provide insight into their advantages over other methods, and consider some possible reasons for failure of the methods to be more broadly adopted, as well as possible remedies. Finally, we consider several extensions of the standard models and estimation methods.
Full work available at URL: https://arxiv.org/abs/1503.01589
Nonparametric estimation (62G05) Applications of statistics to biology and medical sciences; meta analysis (62P10)
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