Sparse Optimal Control of a Phase Field Tumor Model with Mechanical Effects
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Cahn-Hilliard equationelliptic-parabolic systemlinear elasticitymechanical effectsoptimality conditionssparse optimal controltumor growth
Reaction-diffusion equations (35K57) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Existence theories for optimal control problems involving partial differential equations (49J20) Optimality conditions for problems involving partial differential equations (49K20) Variational principles of physics (49S05) Classical linear elasticity (74B05) Cell biology (92C37)
Abstract: In this paper, we study an optimal control problem for a macroscopic mechanical tumour model based on the phase field approach. The model couples a Cahn--Hilliard type equation to a system of linear elasticity and a reaction-diffusion equation for a nutrient concentration. By taking advantage of previous analytical well-posedness results established by the authors, we seek optimal controls in the form of a boundary nutrient supply, as well as concentrations of cytotoxic and antiangiogenic drugs that minimise a cost functional involving mechanical stresses. Special attention is given to sparsity effects, where with the inclusion of convex non-differentiable regularisation terms to the cost functional, we can infer from the first-order optimality conditions that the optimal drug concentrations can vanish on certain time intervals.
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Cited in
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