Structured models of cell migration incorporating molecular binding processes
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Medical applications (general) (92C50) Reaction-diffusion equations (35K57) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Finite volume methods for initial value and initial-boundary value problems involving PDEs (65M08) Computational methods for problems pertaining to biology (92-08) Cell movement (chemotaxis, etc.) (92C17) Cell biology (92C37)
Abstract: The dynamic interplay between collective cell movement and the various molecules involved in the accompanying cell signalling mechanisms plays a crucial role in many biological processes including normal tissue development and pathological scenarios such as wound healing and cancer. Information about the various structures embedded within these processes allows a detailed exploration of the binding of molecular species to cell-surface receptors within the evolving cell population. In this paper we establish a general spatio-temporal-structural framework that enables the description of molecular binding to cell membranes coupled with the cell population dynamics. We first provide a general theoretical description for this approach and then illustrate it with two examples arising from cancer invasion.
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