Some statistical improvements for estimating population size and mutation rate from segregating sites in DNA sequences

DOI10.1006/TPBI.1998.1401MaRDI QIDQ1296931zbMATH OpenOpenAlexWikidataFDO

Authors E. K. Klein, Frédéric Austerlitz, Catherine Larédo

Publication date 3 January 2001

Published in Theoretical Population Biology (Search for Journal in Brave)

Full work available at URL https://semanticscholar.org/paper/9c622168a659247f4417ec3331b4cc54eb26ef4e

zbMATH Keywords

asymptotic normalityrate of convergenceasymptotic efficiencycentral limit theoremconfidence intervalsWatterson estimator

Mathematics Subject Classification ID

Asymptotic properties of parametric estimators (62F12) Applications of statistics to biology and medical sciences; meta analysis (62P10) Asymptotic distribution theory in statistics (62E20) Protein sequences, DNA sequences (92D20)

Recommendations

• Statistical properties of segregating sites
• Asymptotic behavior of the scaled mutation rate estimators
• Sufficiency of the number of segregating sites in the limit under finite-sites mutation
• Sufficiency of the number of segregating sites in the limit under finite-sites mutation

Cites work

• scientific article; zbMATH DE number 3817476 (Why is no real title available?)
• scientific article; zbMATH DE number 3410334 (Why is no real title available?)
• Bootstrap confidence intervals. With comments and a rejoinder by the authors
• Evolution of coalescence times, genetic diversity and structure during colonization
• Genealogy of neutral genes in two partially isolated populations
• Line-of-descent and genealogical processes, and their applications in population genetics models
• On the number of segregating sites in genetical models without recombination
• The coalescent
• Weak convergence and empirical processes. With applications to statistics

Cited in

(15)

• Brownian models and coalescent structures
• Statistical properties of segregating sites
• Sufficiency of the number of segregating sites in the limit under finite-sites mutation
• Efficient Construction of Test Inversion Confidence Intervals Using Quantile Regression
• Estimating the scaled mutation rate and mutation bias with site frequency data
• On the inadmissibility of Watterson's estimator
• Improved inference of mutation rates. I: An integral representation for the Luria-Delbrück distribution
• Statistics of Natural Populations. III. Sequential Sampling Plans for the Estimation of Gene Frequencies
• scientific article; zbMATH DE number 1094272 (Why is no real title available?)
• A non-zero variance of Tajima's estimator for two sequences even for infinitely many unlinked loci
• Estimating change rates of genetic markers using serial samples: applications to the transposon IS6110 in Mycobacterium tuberculosis
• Sufficiency of the number of segregating sites in the limit under finite-sites mutation
• Tajima's D and Site-Specific Nucleotide Frequency in a Population during an Infectious Disease Outbreak
• Asymptotic behavior of the scaled mutation rate estimators
• A generalized Watterson estimator for next-generation sequencing: from trios to autopolyploids

This page was built for publication: Some statistical improvements for estimating population size and mutation rate from segregating sites in DNA sequences

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q1296931)