Some statistical improvements for estimating population size and mutation rate from segregating sites in DNA sequences

DOI10.1006/TPBI.1998.1401zbMATH Open0951.62090OpenAlexW1974853392WikidataQ47263387 ScholiaQ47263387MaRDI QIDQ1296931FDOQ1296931

Authors: E. K. Klein, Frédéric Austerlitz, Catherine Larédo 

Publication date: 3 January 2001

Published in: Theoretical Population Biology (Search for Journal in Brave)

Full work available at URL: https://semanticscholar.org/paper/9c622168a659247f4417ec3331b4cc54eb26ef4e

Recommendations

• Statistical properties of segregating sites
• Asymptotic behavior of the scaled mutation rate estimators
• Sufficiency of the number of segregating sites in the limit under finite-sites mutation
• Sufficiency of the number of segregating sites in the limit under finite-sites mutation

zbMATH Keywords

asymptotic normalityrate of convergenceasymptotic efficiencycentral limit theoremconfidence intervalsWatterson estimator

Mathematics Subject Classification ID

Asymptotic properties of parametric estimators (62F12) Applications of statistics to biology and medical sciences; meta analysis (62P10) Asymptotic distribution theory in statistics (62E20) Protein sequences, DNA sequences (92D20)

Cites Work

• Weak convergence and empirical processes. With applications to statistics
• Bootstrap confidence intervals. With comments and a rejoinder by the authors
• The coalescent
• Title not available (Why is that?)
• Title not available (Why is that?)
• On the number of segregating sites in genetical models without recombination
• Line-of-descent and genealogical processes, and their applications in population genetics models
• Evolution of coalescence times, genetic diversity and structure during colonization
• Genealogy of neutral genes in two partially isolated populations

Cited In (11)

• Estimating change rates of genetic markers using serial samples: applications to the transposon IS6110 in Mycobacterium tuberculosis
• Title not available (Why is that?)
• Improved inference of mutation rates. I: An integral representation for the Luria-Delbrück distribution
• Asymptotic behavior of the scaled mutation rate estimators
• On the inadmissibility of Watterson's estimator
• Brownian models and coalescent structures
• Statistics of Natural Populations. III. Sequential Sampling Plans for the Estimation of Gene Frequencies
• Efficient Construction of Test Inversion Confidence Intervals Using Quantile Regression
• Statistical properties of segregating sites
• Estimating the scaled mutation rate and mutation bias with site frequency data
• Tajima's D and Site-Specific Nucleotide Frequency in a Population during an Infectious Disease Outbreak

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