The type of seeder cells determines the efficiency of germinal center reactions

DOI10.1016/J.BULM.2003.08.003MaRDI QIDQ253501zbMATH OpenOpenAlexWikidataFDO

Authors Tilo Beyer, Michael E. Meyer-Hermann

Publication date 8 March 2016

Published in Bulletin of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/physics/0209009

zbMATH Keywords

all-or-none behaviourgerminal centershumoral immune responsesseeder cells

Mathematics Subject Classification ID

Physiology (general) (92C30) Cell biology (92C37)

Abstract: We discuss the origin of two classes of germinal centers that have been observed during humoral immune responses: Some germinal centers develop very well and give rise to a large number of high affinity antibody producing plasma cells. Other germinal center reaction are very weak and the output production is practically absent. We propose an explanation for this nearly all-or-none behavior of germinal center reactions: The affinity of the seeder B-cells to the antigen is the critical parameter that determines the fate of the germinal center reaction. This hypothesis is verified in the framework of a space-time simulation of germinal center reactions.

Recommendations

• An analysis of B cell selection mechanisms in germinal centers
• Germinal center dynamics during acute and chronic infection
• A spatial model of germinal center reactions: cellular adhesion based sorting of B cells results in efficient affinity maturation
• The role of geometric features in a germinal center
• Dynamics of one-pass germinal center models: implications for affinity maturation
• Mathematical modeling of lymphocytes selection in the germinal center
• A CONCERTED ACTION OF B CELL SELECTION MECHANISMS
• The influence of T cell development on pathogen specificity and autoreactivity
• T cell development in the thymus: from periodic seeding to constant output
• scientific article; zbMATH DE number 2193316

Cited in

(4)

• Are T cells at the origin of B cell lymphomas?
• A CONCERTED ACTION OF B CELL SELECTION MECHANISMS
• Antigen-driven selection in germinal centers as reflected by the shape characteristics of immunoglobulin gene lineage trees: a large-scale simulation study
• A spatial model of germinal center reactions: cellular adhesion based sorting of B cells results in efficient affinity maturation

This page was built for publication: The type of seeder cells determines the efficiency of germinal center reactions

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q253501)