The type of seeder cells determines the efficiency of germinal center reactions

DOI10.1016/J.BULM.2003.08.003zbMATH Open1334.92119arXivphysics/0209009OpenAlexW2090391670WikidataQ79361815 ScholiaQ79361815MaRDI QIDQ253501FDOQ253501

Authors: Tilo Beyer, Michael E. Meyer-Hermann 

Publication date: 8 March 2016

Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)

Abstract: We discuss the origin of two classes of germinal centers that have been observed during humoral immune responses: Some germinal centers develop very well and give rise to a large number of high affinity antibody producing plasma cells. Other germinal center reaction are very weak and the output production is practically absent. We propose an explanation for this nearly all-or-none behavior of germinal center reactions: The affinity of the seeder B-cells to the antigen is the critical parameter that determines the fate of the germinal center reaction. This hypothesis is verified in the framework of a space-time simulation of germinal center reactions.

Full work available at URL: https://arxiv.org/abs/physics/0209009

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zbMATH Keywords

all-or-none behaviourgerminal centershumoral immune responsesseeder cells

Mathematics Subject Classification ID

Physiology (general) (92C30) Cell biology (92C37)

Cited In (4)

• Are T cells at the origin of B cell lymphomas?
• A spatial model of germinal center reactions: cellular adhesion based sorting of B cells results in efficient affinity maturation
• Antigen-driven selection in germinal centers as reflected by the shape characteristics of immunoglobulin gene lineage trees: a large-scale simulation study
• A CONCERTED ACTION OF B CELL SELECTION MECHANISMS

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