An analysis of B cell selection mechanisms in germinal centers

DOI10.1093/IMAMMB/DQL012zbMATH Open1098.92041OpenAlexW2097591929WikidataQ51941541 ScholiaQ51941541MaRDI QIDQ3408340FDOQ3408340

Authors Philip K. Maini, Dagmar Iber, Michael E. Meyer-Hermann 

Publication date 31 October 2006

Published in Mathematical Medicine and Biology: A Journal of the IMA (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/q-bio/0611046

zbMATH Keywords

lymphocytesgerminal centreB cell selection

Mathematics Subject Classification ID

Medical applications (general) (92C50) Cell biology (92C37)

Abstract: Affinity maturation of antibodies during immune responses is achieved by multiple rounds of somatic hypermutation and subsequent preferential selection of those B cells that express B cell receptors with improved binding characteristics for the antigen. The mechanism underlying B cell selection has not yet been defined. By employing an agent-based model, we show that for physiologically reasonable parameter values affinity maturation can neither be driven by competition for binding sites nor antigen -- even in the presence of competing secreted antibodies. Within the tested mechanisms, only clonal competition for T cell help or a refractory time for the interaction of centrocytes with follicular dendritic cells are found to enable affinity maturation while generating the experimentally observed germinal center characteristics and tolerating large variations in the initial antigen density.

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• The role of the T-helper/T-suppressor ratio in the adaptive immune response: a dynamical model
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• Diversity against adversity: how adaptive immune system evolves potent antibodies
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