Statistical inference from genetic data on pedigrees
Applications of statistics to biology and medical sciences; meta analysis (62P10) Introductory exposition (textbooks, tutorial papers, etc.) pertaining to biology (92-01) Research exposition (monographs, survey articles) pertaining to biology (92-02) Genetics and epigenetics (92D10) Problems related to evolution (92D15)
This monograph is based primarily on material presented at the Conference Board of the Mathematical Sciences Summer Course on ``Inferences from genetic data on pedigrees given at Michigan Technical University in 1999. It is not a textbook: it contains no exercises and is insufficiently detailed for that purpose. It is possible to use it as a textbook, either in conjunction with another book, or by advanced students who will consult the cited literature for details. The Contents are the following:NEWLINENEWLINENEWLINE1. Genes, pedigrees and genetic models; 2. Likelihood, estimation and testing; 3. Gene identity by descent; 4. Genetic linkage; 5. Models for meiosis; 6. Likelihoods on pedigrees; 7. Monte Carlo estimates on pedigrees; 8. Markov chain Monte Carlo on pedigrees; 9. Likelihood ratios for genetic analysis; 10. Case studies using the \(M\)- and \(LM\)-samplers; 11. Other Monte Carlo likelihoods in genetics.NEWLINENEWLINENEWLINEThe notes used at the above mentioned Summer Course have been augmented by material from two lecture classes given at the University of Washington. A number of 22 useful tables are given. The monograph can serve at least the following two purposes: a) an introductory course could cover the Chapters 1-4, with final material taken from Sections 6.1, 6.2, 7.1 and 7.2; b) more advanced students could work through the entire monograph.
- Locating multiple interacting quantitative trait loci using robust model selection
- Mathematical and statistical methods for genetic analysis
- Graphical models for genetic analyses
- Discovering disease genes: multipoint linkage analysis via a new Markov chain Monte Carlo approach
- Reconstructing pedigrees: a stochastic perspective
- Reconstructing pedigrees using probabilistic analysis of ISSR amplification
- Is EM really necessary here? Examples where it seems simpler not to use EM
- Reconstructing pedigrees: a combinatorial perspective
- On reducing the statespace of hidden Markov models for the identity by descent process
- Multiple interval mapping for quantitative trait loci via EM algorithm in the presence of crossover interference
- Improving Estimates of Genetic Maps: A Maximum Likelihood Approach
- Inferring Gene Ancestry: Estimating Gene Descent
- scientific article; zbMATH DE number 1984444 (Why is no real title available?)
- scientific article; zbMATH DE number 1750194 (Why is no real title available?)
- scientific article; zbMATH DE number 2147958 (Why is no real title available?)
- ROBUST NON-PARAMETRIC ESTIMATION OF GENOTYPE-PHENOTYPE RELATIONSHIPS IN HUMAN PEDIGREES
- Bayesian MCMC Mapping of Quantitative Trait Loci in a Half-sib Design: a Graphical Model Perspective
- Improved maximum likelihood reconstruction of complex multi-generational pedigrees
- scientific article; zbMATH DE number 934452 (Why is no real title available?)
- Reward distributions associated with some block tridiagonal transition matrices with applications to identity by descent
- Reconstruction of pedigrees in clonal plant populations
- Reconstruction of pedigrees in clonal plant populations
- A parametric approach to kinship hypothesis testing using identity-by-descent parameters
- An n th-Cousin Mating Model and the n -Anacci Numbers
- Unattainable regions in the space of genetic relationships
- Relatedness coefficients in pedigrees with inbred founders
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