Asymptotic analysis of a TMDD model: when a reaction contributes to the destruction of its product

DOI10.1007/S00285-018-1234-XMaRDI QIDQ667708zbMATHOpenAlexWikidataFDO

Authors Lida I. Michalaki, Dimitrios A. Goussis

Publication date 1 March 2019

Published in Journal of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1007/s00285-018-1234-x

zbMATH Keywords

perturbation analysiscomputational singular perturbation (CSP)partial equilibrium approximation (PEA)quasi-steady-state approximation (QSSA)target-mediated drug disposition (TMDD)

Mathematics Subject Classification ID

Qualitative investigation and simulation of ordinary differential equation models (34C60) Geometric methods in ordinary differential equations (34A26) Invariant manifolds for ordinary differential equations (34C45) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Computational methods for bifurcation problems in dynamical systems (37M20) Singular perturbations, turning point theory, WKB methods for ordinary differential equations (34E20)

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Cites work

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Cited in

(8)

• Geometric singular perturbation analysis of a dynamical target mediated drug disposition model
• A new Michaelis-Menten equation valid everywhere multi-scale dynamics prevails
• Dynamics of target-mediated drug disposition: how a drug reaches its target
• Asymptotic analysis of a target-mediated drug disposition model: algorithmic and traditional approaches
• Steady-state drug exposure of repeated IV bolus administration for a one compartment pharmacokinetic model with sigmoidal Hill elimination
• A mathematical analysis of rebound in a target-mediated drug disposition model. II. With feedback
• Algorithmic criteria for the validity of quasi-steady state and partial equilibrium models: the Michaelis-Menten reaction mechanism
• Dynamics of a two-receptor binding model: how affinities and capacities translate into long and short time behaviour and physiological corollaries

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