Asymptotic analysis of a TMDD model: when a reaction contributes to the destruction of its product
DOI10.1007/S00285-018-1234-XzbMATH Open1417.34104OpenAlexW2802846012WikidataQ52314632 ScholiaQ52314632MaRDI QIDQ667708FDOQ667708
Authors: Lida I. Michalaki, Dimitrios A. Goussis 
Publication date: 1 March 2019
Published in: Journal of Mathematical Biology (Search for Journal in Brave)
Full work available at URL: https://doi.org/10.1007/s00285-018-1234-x
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perturbation analysiscomputational singular perturbation (CSP)partial equilibrium approximation (PEA)quasi-steady-state approximation (QSSA)target-mediated drug disposition (TMDD)
Qualitative investigation and simulation of ordinary differential equation models (34C60) Geometric methods in ordinary differential equations (34A26) Invariant manifolds for ordinary differential equations (34C45) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Computational methods for bifurcation problems in dynamical systems (37M20) Singular perturbations, turning point theory, WKB methods for ordinary differential equations (34E20)
Cites Work
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Cited In (4)
- Dynamics of a two-receptor binding model: how affinities and capacities translate into long and short time behaviour and physiological corollaries
- Steady-state drug exposure of repeated IV bolus administration for a one compartment pharmacokinetic model with sigmoidal Hill elimination
- A new Michaelis-Menten equation valid everywhere multi-scale dynamics prevails
- Algorithmic criteria for the validity of quasi-steady state and partial equilibrium models: the Michaelis-Menten reaction mechanism
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