A theoretical investigation of the effect of proliferation and adhesion on monoclonal conversion in the colonic crypt

DOI10.1016/J.JTBI.2012.08.002zbMath1337.92049OpenAlexW2129391320WikidataQ51331898 ScholiaQ51331898MaRDI QIDQ293806

Alexander G. Fletcher, Gary R. Mirams, Philip K. Maini, Helen M. Byrne

Publication date: 9 June 2016

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://ora.ox.ac.uk/objects/uuid:c99ab09b-e2dd-4b3e-945e-364d65da4349

zbMATH Keywords

mathematical modelmutationclonal expansioncolorectal cryptstem cell

Mathematics Subject Classification ID

Medical applications (general) (92C50) Cell biology (92C37)

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Uses Software

• Unnamed Item

Cites Work

• Chaste: A test-driven approach to software development for biological modelling
• Modelling the role of the basement membrane beneath a growing epithelial monolayer
• Mathematical modeling of monoclonal conversion in the colonic crypt
• Individual-based models to growth and folding in one-layered tissues: intestinal crypts and early development.
• Elucidating the interactions between the adhesive and transcriptional functions of \(\beta\)-catenin in normal and cancerous cells
• A multiple timescale analysis of a mathematical model of the Wnt/\(\beta\)-catenin signalling pathway
• Biomechanical modelling of colorectal crypt budding and fission
• Loss- and gain-of-function mutations in cancer: mass-action, spatial and hierarchical models
• A hybrid approach to multi-scale modelling of cancer
• Continuum approximations of individual-based models for epithelial monolayers
• Markov Chains

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