The dynamics of an optimally controlled tumor model: A case study

DOI10.1016/S0895-7177(03)00133-XzbMath1043.92018MaRDI QIDQ1433148

L. G. de Pillis, A. E. Radunskaya

Publication date: 15 June 2004

Published in: Mathematical and Computer Modelling (Search for Journal in Brave)

zbMATH Keywords

optimal controlordinary differential equationscancermathematical modellingcompetition modelspopulation modelsimmune systemtumor

Mathematics Subject Classification ID

Applications of optimal control and differential games (49N90) Topological structure of integral curves, singular points, limit cycles of ordinary differential equations (34C05) Dynamical systems in biology (37N25) Medical applications (general) (92C50) Qualitative investigation and simulation of ordinary differential equation models (34C60)

Cites Work

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• Optimal control for a cancer chemotherapy problem with general growth and loss functions
• Mathematical model of cancer chemotherapy. Periodic schedules of phase- specific cytotoxic-agent administration increasing the selectivity of therapy
• Modeling immunotherapy of the tumor -- immune interaction
• Nonlinear dynamics of immunogenic tumors: Parameter estimation and global bifurcation analysis
• Singularity of optimal control in some problems related to optimal chemotherapy
• Asymptotically autonomous differential equations in the plane
• Optimal drug regimens in cancer chemotherapy for single drugs that block progression through the cell cycle
• Chemotherapeutic treatments: A study of the interplay among drug resistance, toxicity and recuperation from side effects
• Conflicting objectives in chemotherapy with drug resistance
• A logistic model of periodic chemotherapy with drug resistance
• The influence of fixed and free final time of treatment on optimal chemotherapeutic protocols
• Modelling and mathematical problems related to tumor evolution and its interaction with the immune system
• Chemotherapeutic treatments involving drug resistance and level of normal cells as a criterion of toxicity
• Cancer chemotherapy optimization under evolving drug resistance.
• Balancing survival and extinction in nonautonomous competitive Lotka- Volterra systems
• A simple mathematical model and alternative paradigm for certain chemotherapeutic regimens
• A mathematical model of periodically pulsed chemotherapy: Tumor recurrence and metastasis in a competitive environment
• A mathematical model of cancer treatment by immunotherapy
• A mathematical model of cancer chemotherapy with an optimal selection of parameters
• The dynamics of growth-factor-modified immune response to cancer growth: One dimensional models
• A Mathematical Tumor Model with Immune Resistance and Drug Therapy: An Optimal Control Approach
• Systems of differential equations which are competitive or cooperative: III. Competing species
• Extinction in nonautonomous competitive Lotka-Volterra systems
• Extinction in Competitive Lotka-Volterra Systems
• Three-Dimensional Competitive Lotka--Volterra Systems with no Periodic Orbits
• TUMOR/IMMUNE SYSTEM COMPETITION WITH MEDICALLY INDUCED ACTIVATION/DEACTIVATION
• MATHEMATICAL MODELLING OF MACROPHAGE DYNAMICS IN TUMOURS
• USING COMPUTER SIMULATIONS FOR EVALUATING THE EFFICACY OF BREAST CANCER CHEMOTHERAPY PROTOCOLS
• Optimal Control Applied to Cell-Cycle-Specific Cancer Chemotherapy
• Modeling tumor regrowth and immunotherapy

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