Statistical methods for the analysis of high-throughput data based on functional profiles derived from the Gene Ontology

DOI10.1016/J.JSPI.2007.04.015MaRDI QIDQ2455419zbMATH OpenOpenAlexWikidataFDO

Authors Alex Sánchez, Miguel Salicrú, Jordi Ocanã

Publication date 24 October 2007

Published in Journal of Statistical Planning and Inference (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jspi.2007.04.015

zbMATH Keywords

microarraysfunctional profile

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Biochemistry, molecular biology (92C40) Genetics and epigenetics (92D10) Protein sequences, DNA sequences (92D20)

Recommendations

• New Trends in the Analysis of Functional Genomic Data
• Using enriched ontology structure for improving statistical models of gene annotation sets
• A Bayesian extension of the hypergeometric test for functional enrichment analysis
• A model-based analysis to infer the functional content of a gene list
• Contextual analysis of gene expression data.

Cites work

• Approximation Theorems of Mathematical Statistics
• DNA microarray experiments: biological and technological aspects
• Significance analysis of microarrays applied to the ionizing radiation response
• THE DISTRIBUTION OF GENERAL QUADRATIC FORMS IN NORMA
• The Analysis of Categorical Data From Complex Sample Surveys: Chi-Squared Tests for Goodness of Fit and Independence in Two-Way Tables

Cited in

(7)

• New Trends in the Analysis of Functional Genomic Data
• A Bayesian extension of the hypergeometric test for functional enrichment analysis
• A multi-functional analyzer uses parameter constraints to improve the efficiency of model-based gene-set analysis
• An Improved Statistic for Detecting Over-Represented Gene Ontology Annotations in Gene Sets
• scientific article; zbMATH DE number 5262750 (Why is no real title available?)
• Using enriched ontology structure for improving statistical models of gene annotation sets
• Using GO for statistical analyses

Describes a project that uses

Uses Software

• R
• Bioconductor
• gcrma
• limma
• FatiGO
• goTools
• DAVID

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