Time-delayed models of gene regulatory networks
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Publication:307714
DOI10.1155/2015/347273zbMATH Open1343.92168DBLPjournals/cmmm/ParmarBKH15arXiv1510.08513OpenAlexW1877666302WikidataQ38635679 ScholiaQ38635679MaRDI QIDQ307714FDOQ307714
S. J. Hogan, K. Parmar, Y. N. Kyrychko, K. B. Blyuss
Publication date: 5 September 2016
Published in: Computational \& Mathematical Methods in Medicine (Search for Journal in Brave)
Abstract: In this review we discuss different mathematical models of gene regulatory networks as relevant to the onset and development of cancer. After discussion of alternative modelling approaches, we use a paradigmatic two-gene network to focus on the role played by time delays in the dynamics of gene regulatory networks. We contrast the dynamics of the reduced model arising in the limit of fast mRNA dynamics with that of the full model. The review concludes with the discussion of some open problems.
Full work available at URL: https://arxiv.org/abs/1510.08513
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Cited In (14)
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