Continual Reassessment Method: A Likelihood Approach

DOI10.2307/2532905zbMath0925.62454OpenAlexW2312270541WikidataQ52304573 ScholiaQ52304573MaRDI QIDQ4335691

John O'Quigley, Larry Zaiqian Shen

Publication date: 12 June 1997

Published in: Biometrics (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.2307/2532905

zbMATH Keywords

maximum likelihoodtoxicitydose escalationdose finding studiesphase 1 trial

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Related Items (29)

Continual Reassessment Method for Partial Ordering ⋮ Designs for Single- or Multiple-Agent Phase I Trials ⋮ Phase I (or Phase II) Dose-Ranging Clinical Trials: Proposal of a Two-Stage Bayesian Design ⋮ The role of minimal sets in dose finding studies ⋮ A new design of the continual reassessment method ⋮ Escalation with overdose control using ordinal toxicity grades for cancer phase I clinical trials ⋮ Continual reassessment and related dose-finding designs ⋮ The adaptive accelerated biased coin design for phase I clinical trials ⋮ Adaptive clinical trial designs for phase I cancer studies ⋮ Retrospective Analysis of Sequential Dose‐Finding Designs ⋮ A class of designs for Phase I cancer clinical trials combining Bayesian and likelihood approaches ⋮ Ethical considerations concerning treatment allocation in drug development trials ⋮ A Curve‐Free Method for Phase I Clinical Trials ⋮ The Continual Reassessment Method for Multiple Toxicity Grades: A Bayesian Quasi‐Likelihood Approach ⋮ Sequential Designs for Phase I Clinical Trials with Late‐Onset Toxicities ⋮ Theoretical study of the continual reassessment method ⋮ Designs for Phase I Clinical Trials with Multiple Courses of Subjects at Different Doses ⋮ The Continual Reassessment Method for Multiple Toxicity Grades: A Bayesian Quasi‐Likelihood Approach ⋮ A Hierarchical Bayesian Design for Phase I Trials of Novel Combinations of Cancer Therapeutic Agents ⋮ Analysis of ``learn-as-you-go (LAGO) studies ⋮ Dose-Finding Based on Feasibility and Toxicity in T-cell Infusion Trials ⋮ Dose-Finding Designs for HIV Studies ⋮ Curve-Free and Model-Based Continual Reassessment Method Designs ⋮ A Simple Technique to Evaluate Model Sensitivity in the Continual Reassessment Method ⋮ Continual Reassessment Method for Ordered Groups ⋮ A new sequential approximation method ⋮ Flexible link continual reassessment methods for trivariate binary outcome phase I/II trials ⋮ Operating characteristics of the standard phase I clinical trial design. ⋮ Bayesian Dose-Finding in Phase I/II Clinical Trials Using Toxicity and Efficacy Odds Ratios

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