Shrinkage of dispersion parameters in the binomial family, with application to differential exon skipping

DOI10.1214/15-AOAS871zbMath1400.62284MaRDI QIDQ312910

Sean Ruddy, Marla Johnson, Elizabeth Purdom

Publication date: 9 September 2016

Published in: The Annals of Applied Statistics (Search for Journal in Brave)

Full work available at URL: https://projecteuclid.org/euclid.aoas/1469199890

zbMATH Keywords

empirical Bayes; alternative splicing; dispersion estimation; mRNA-Seq; over-dispersed binomial

Mathematics Subject Classification ID

62J07: Ridge regression; shrinkage estimators (Lasso)

62P10: Applications of statistics to biology and medical sciences; meta analysis

92D20: Protein sequences, DNA sequences

62C12: Empirical decision procedures; empirical Bayes procedures

Uses Software

• R
• Bioconductor
• CRAN
• gcrma
• edgeR
• BaySeq
• DEseq
• limma
• Voom
• DoubleExpSeq
• DiffSplice
• TopHat
• EBSeq
• MOABS
• rSeqDiff
• SpliceTrap