Asymptotic analysis of a target-mediated drug disposition model: algorithmic and traditional approaches

DOI10.1007/s11538-016-0176-yzbMath1348.92075OpenAlexW2413977353WikidataQ50631888 ScholiaQ50631888MaRDI QIDQ312612

Dimitris G. Patsatzis, Dimitris T. Maris, Dimitrios A. Goussis

Publication date: 16 September 2016

Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1007/s11538-016-0176-y

zbMATH Keywords

CSPsingular perturbation analysisPEAQSSATMDD

Mathematics Subject Classification ID

Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Biochemistry, molecular biology (92C40)

Related Items (6)

Impact of enzyme turnover on the dynamics of the Michaelis-Menten model ⋮ Asymptotic analysis of a TMDD model: when a reaction contributes to the destruction of its product ⋮ Geometric singular perturbation analysis of a dynamical target mediated drug disposition model ⋮ Algorithmic asymptotic analysis: extending the arsenal of cancer immunology modeling ⋮ A new Michaelis-Menten equation valid everywhere multi-scale dynamics prevails ⋮ NH₃ vs. CH₄ autoignition: A comparison of chemical dynamics

Cites Work

• Unnamed Item
• Unnamed Item
• Unnamed Item
• Unnamed Item
• Geometric analysis of the Goldbeter minimal model for the embryonic cell cycle
• Challenges in pharmacology modelling
• Topics in mathematical pharmacology
• Multiple time scale dynamics
• Quasi steady-state approximations in complex intracellular signal transduction networks - a word of caution
• Constraint-defined manifolds: a legacy code approach to low-dimensional computation
• On the validity of the quasi-steady state approximation of bimolecular reactions in solution
• A geometric analysis of fast-slow models for stochastic gene expression
• Perturbation methods in applied mathematics
• Geometric singular perturbation theory for ordinary differential equations
• Mathematical physiology
• Asymptotic analysis of two reduction methods for systems of chemical reactions
• Mathematical analysis of the pharmacokinetic-pharmacodynamic (PKPD) behaviour of monoclonal antibodies: predicting \textit{in vivo} potency
• Analysis of the computational singular perturbation reduction method for chemical kinetics
• The role of slow system dynamics in predicting the degeneracy of slow invariant manifolds: the case of vdP relaxation-oscillations
• Physical understanding of complex multiscale biochemical models via algorithmic simplification: glycolysis in saccharomyces cerevisiae
• Geometric singular perturbation theory in biological practice
• Determining ``small parameters for quasi-steady state
• The ``hidden dynamics of the Rössler attractor
• Methods of small parameter in mathematical biology
• Higher order corrections in the approximation of low-dimensional manifolds and the construction of simplified problems with the CSP method
• An efficient iterative algorithm for the approximation of the fast and slow dynamics of stiff systems
• Algorithmic asymptotic analysis of the NF-\(\kappa\mathrm B\) signaling system
• Glycolysis in saccharomyces cerevisiae: algorithmic exploration of robustness and origin of oscillations
• Small periodic perturbations of an autonomous system with a stable orbit
• Invariant manifold methods for metabolic model reduction
• Analysis of Kinetic Reaction Mechanisms
• Rescue of the Quasi‐Steady‐State Approximation in a Model for Oscillations in an Enzymatic Cascade
• Geometry of the Computational Singular Perturbation Method
• Quasi-Steady State and Nearly Invariant Sets
• Asymptotic Solution of Stiff PDEs with the CSP Method: The Reaction Diffusion Equation
• Model Reduction for Combustion Chemistry
• Fast and Slow Dynamics for the Computational Singular Perturbation Method
• The Quasi-Steady-State Assumption: A Case Study in Perturbation
• Quasi steady state and partial equilibrium approximations: their relation and their validity
• H₂/air autoignition: The nature and interaction of the developing explosive modes
• Model Reduction and Physical Understanding of Slowly Oscillating Processes: The Circadian Cycle
• ASYMPTOTIC BEHAVIOUR OF SOLUTIONS TO CERTAIN PROBLEMS INVOLVING NON-LINEAR DIFFERENTIAL EQUATIONS CONTAINING A SMALL PARAMETER MULTIPLYING THE HIGHEST DERIVATIVES
• Projecting to a Slow Manifold: Singularly Perturbed Systems and Legacy Codes
• Invariant manifolds

This page was built for publication: Asymptotic analysis of a target-mediated drug disposition model: algorithmic and traditional approaches