Using gene expression noise to understand gene regulation
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Publication:2962015
DOI10.1126/SCIENCE.1216379zbMATH Open1355.92069OpenAlexW1984429906WikidataQ24617979 ScholiaQ24617979MaRDI QIDQ2962015FDOQ2962015
Authors: Brian Munsky, Gregor Neuert, Alexander van Oudenaarden 
Publication date: 15 February 2017
Published in: Science (Search for Journal in Brave)
Full work available at URL: http://europepmc.org/articles/pmc3358231
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Cited In (53)
- The dynamics of gene transcription Induced by variation in transcription kinetics
- Phase separation reduces cell-to-cell variability of transcriptional bursting
- Analytical results for a non-Markovian process of gene expression with positive and negative feedbacks
- External noise control in inherently stochastic biological systems
- A model of gene expression based on random dynamical systems reveals modularity properties of gene regulatory networks
- Analytical formula and dynamic profile of mRNA distribution
- Stochastic modelling of slow-progressing tumors: analysis and applications to the cell interplay and control of low grade gliomas
- A generalized moment-based method for estimating parameters of stochastic gene transcription
- Analysis and Design of Jump Coefficients in Discrete Stochastic Diffusion Models
- Modeling stochastic gene expression in growing cells
- Multiscale modeling of diffusion in a crowded environment
- Limits of noise for autoregulated gene expression
- Search of stochastically gated targets with diffusive particles under resetting
- An efficient and assumption-free method to approximate protein level distribution in the two-states gene expression model
- Rethinking the evolution of specialization: a model for the evolution of phenotypic heterogeneity
- Switches in a genetic regulatory system under multiplicative non-Gaussian noise
- Fluctuation effects in gene regulation by microRNAs and correlations between gene and pseudogene mRNAs in the control of cancer
- Multiscale Simulation of Stochastic Reaction-Diffusion Networks
- Impacts of the cross-correlated noises on the fluctuation behaviors of a gene transcriptional regulatory system
- Reaction dynamics under confinement: an exact path integral treatment of a two-stage model of stochastic gene expression
- Doubly stochastic (pseudo)gene expression in the regulation of cancer
- Noise control and utility: from regulatory network to spatial patterning
- Distribution Modes and Their Corresponding Parameter Regions in Stochastic Gene Transcription
- Method of conditional moments (MCM) for the chemical master equation
- Gene expression noise is affected differentially by feedback in burst frequency and burst size
- The dynamics of gene transcription in random environments
- Protein noise and distribution in a two-stage gene-expression model extended by an mRNA inactivation loop
- Feedback-Induced Variations of Distribution in a Representative Gene Model
- Inference on autoregulation in gene expression with variance-to-mean ratio
- Characteristics of promoter architecture-dependent expression noise and bursting kinetics
- Stochastic reaction-diffusion processes with embedded lower-dimensional structures
- Nonlinear dynamics and noise actuated by the cycle of gene inactivation in stochastic transcription
- Fluctuations of mRNA distributions in multiple pathway activated transcription
- Markovian dynamics on complex reaction networks
- Simulation of stochastic diffusion via first exit times
- High cooperativity in negative feedback can amplify noisy gene expression
- MONOTONIC DYNAMICS OF MRNA DEGRADATION BY TWO PATHWAYS
- Quantitative noise analysis for gene expression microarray experiments
- Effects of elongation delay in transcription dynamics
- Likelihood for transcriptions in a genetic regulatory system under asymmetric stable Lévy noise
- A structured population modeling framework for quantifying and predicting gene expression noise in flow cytometry data
- Dynamical regulation of mRNA distribution by cross-talking signaling pathways
- Mixture distributions in a stochastic gene expression model with delayed feedback: a WKB approximation approach
- Most probable transition pathways and maximal likely trajectories in a genetic regulatory system
- Modulation of gene transcription noise by competing transcription factors
- Postponing production exponentially enhances the molecular memory of a stochastic switch
- Decomposition and tunability of expression noise in the presence of coupled feedbacks
- Control of noise in gene expression by transcriptional reinitiation
- CHARACTERIZATION OF INTRINSIC AND EXTRINSIC NOISE EFFECTS IN POSITIVELY REGULATED GENES
- Theory of transcription bursting: stochasticity in the transcription rates
- A comparative analysis of noise properties of stochastic binary models for a self-repressing and for an externally regulating gene
- The mean and noise of stochastic gene transcription with cell division
- Quantifying heterogeneity of stochastic gene expression
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