On optimal delivery of combination therapy for tumors
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Publication:1042733
DOI10.1016/J.MBS.2009.08.004zbMath1176.92033OpenAlexW2091513278WikidataQ51798408 ScholiaQ51798408MaRDI QIDQ1042733
Heinz Schättler, Helmut Maurer, Alberto d'Onofrio, Urszula Łedzewicz-Kowalewska
Publication date: 7 December 2009
Published in: Mathematical Biosciences (Search for Journal in Brave)
Full work available at URL: https://doi.org/10.1016/j.mbs.2009.08.004
Applications of optimal control and differential games (49N90) Medical applications (general) (92C50) Existence theories for optimal control problems involving ordinary differential equations (49J15)
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Cites Work
- Unnamed Item
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- Unnamed Item
- Optimal scheduling of radiotherapy and angiogenic inhibitors
- Optimal control in a model of dendritic cell transfection cancer immunotherapy
- Critical-point analysis for three-variable cancer angiogenesis models
- Tutorials in mathematical biosciences III. Cell cycle, prolifereation, and cancer.
- Scheduling of angiogenic inhibitors for Gompertzian and logistic tumor growth models
- The response to antiangiogenic anticancer drugs that inhibit endothelial cell proliferation
- Multiscale modelling of tumour growth and therapy: the influence of vessel normalisation on chemotherapy
- Role of optimal control theory in cancer chemotherapy
- Optimal controls for a model with pharmacokinetics maximizing bone marrow in cancer chemo\-therapy
- Stochastic modelling of tumour-induced angiogenesis
- On the optimality of singular controls for a class of mathematical models for tumor anti-angiogenesis
- Continuous and discrete mathematical models of tumor-induced angiogenesis
- Optimal control of the chemotherapy of HIV
- SQP-methods for solving optimal control problems with control and state constraints: Adjoint variables, sensitivity analysis and real-time control
- Optimal and suboptimal protocols for a class of mathematical models of tumor anti-angiogenesis
- Singular trajectories and their role in control theory
- Optimal bang-bang controls for a two-compartment model in cancer chemotherapy
- Tumour eradication by antiangiogenic therapy: analysis and extensions of the model by Hahnfeldt et al. (1999)
- Vascular network remodeling via vessel cooption, regression and growth in tumors
- A bi-parametric model for the tumour angiogenesis and antiangiogenesis therapy
- Modelling the role of angiogenesis and vasculogenesis in solid tumour growth
- A general framework for modeling tumor-immune system competition and immunotherapy: Mathematical analysis and biomedical inferences
- A Mathematical Tumor Model with Immune Resistance and Drug Therapy: An Optimal Control Approach
- AntiAngiogenic Therapy in Cancer Treatment as an Optimal Control Problem
- Realizable protocols for optimal administration of drugs in mathematical models for anti-angiogenic treatment
- A family of models of angiogenesis and anti-angiogenesis anti-cancer therapy
- Optimal Control Applied to Cell-Cycle-Specific Cancer Chemotherapy
- ANALYSIS OF A CELL-CYCLE SPECIFIC MODEL FOR CANCER CHEMOTHERAPY
- Simple ODE models of tumor growth and anti-angiogenic or radiation treatment
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